If your wiki does not have a root URL (like http://www.example.com/FrontPage), then you might need to follow the next steps:
On some installations, mod_python hands MoinMoin incorrect script_name and path_info. It usually happens when using the Apache Location directive, with a wiki in an arbitary path:
<Location /farm/mywiki> ... </Location>
This will not work, because its not clear what is the script name, since with location setup, there is no real script.
To solve this problem, use a PythonOption directive:
<Location /farm/mywiki> # Location value must match the Apache Location value! PythonOption Location /farm/mywiki ... </Location>