Many popular Apache modules for "fast web serving," like mod_python and mod_perl, are incompatible with our security requirements; they force all Python, Perl, etc., scripts run through them to run as a single UNIX user. Thus, to use these modules, you will need to run your own separate web server. See RunningYourOwnApache. You will probably want to run lighttpd instead of your own Apache, since configuring it is much simpler.
It also couldn't hurt to petition the authors of these modules to fix this problem.